Karim Guédé, native of Hamburg, is a son of Togolese mother and French father. After playing for the Oberliga Hamburg club SC Concordia and Hamburger SV reserve he came to Artmedia Petržalka in July 2006. He made his the Corgoň Liga debut in a 4–0 defeat against Trenčín on 9 September 2006. He began playing as a defensive midfielder in Artmedia, previously he played as a defender. In the next season he won the Double. He moved to Slovan Bratislava in January 2010. In his first season in a new club he won the Slovak Cup. He won his second the Slovak Double in 2010–11. After 5 years in Slovakia he obtained Slovak citizenship and became a possible choice for the national team manager Vladimír Weiss.
Karim Guédé made his the national team debut in the 2–1 away win against Austria on 10 August 2011.
Corgoň Liga (1): 2007–08
Slovak Cup (1): 2007–08
Corgoň Liga (1): 2010–11
Slovak Cup (2): 2009–10, 2010–11
SC Freiburg 2012-